Pharmacy Practice MCQ » PHARMACAREERS

Pharmacy Practice MCQ, in this article we will solve, Practice MCQ under subject physical pharmaceutics. Read following article for your reference.

Physicochemical Properties Of Drug Molecules » PHARMACAREERS

Which of the following is a key physicochemical property affecting drug solubility?
- A) Molecular weight
- B) Partition coefficient
- C) Melting point
- D) All of the above
What does the partition coefficient (log P) indicate?
- A) The solubility of a drug in water
- B) The ratio of a drug’s solubility in octanol to water
- C) The dissociation constant of a drug
- D) The molecular weight of a drug
Which property is crucial for passive diffusion across cell membranes?
- A) Lipophilicity
- B) Ionization
- C) Hydrogen bonding
- D) Molecular size
What is the significance of a drug’s dissociation constant (pKa)?
- A) It determines the drug’s solubility in water
- B) It indicates the drug’s ability to ionize at a given pH
- C) It measures the drug’s partition coefficient
- D) It reflects the drug’s molecular weight
Which physicochemical property is most important for drug absorption in the gastrointestinal tract?
- A) Lipophilicity
- B) Hydrogen bonding
- C) Molecular size
- D) Ionization
What does a high log P value suggest about a drug?
- A) High water solubility
- B) High lipid solubility
- C) Low molecular weight
- D) High ionization
Which of the following affects a drug’s bioavailability?
- A) Solubility
- B) Permeability
- C) Stability
- D) All of the above
What is the role of hydrogen bonding in drug molecules?
- A) Enhances solubility in water
- B) Increases molecular weight
- C) Reduces lipophilicity
- D) Decreases ionization
Which property is used to predict a drug’s pharmacokinetic behavior?
- A) Partition coefficient
- B) Dissociation constant
- C) Molecular size
- D) All of the above
What does the term ‘bioavailability’ refer to?
- A) The rate and extent of drug absorption
- B) The drug’s solubility in water
- C) The drug’s partition coefficient
- D) The drug’s molecular weight
Which factor can influence the ionization of a drug?
- A) pH of the environment
- B) Molecular weight
- C) Partition coefficient
- D) Hydrogen bonding
What is the impact of high molecular weight on drug absorption?
- A) Enhances absorption
- B) Reduces absorption
- C) No impact on absorption
- D) Increases solubility
Which property is crucial for drug distribution in the body?
- A) Lipophilicity
- B) Hydrogen bonding
- C) Ionization
- D) Molecular size
What does a low pKa value indicate about a drug?
- A) It is a strong acid
- B) It is a weak acid
- C) It is a strong base
- D) It is a weak base
Which property affects the drug’s ability to cross the blood-brain barrier?
- A) Lipophilicity
- B) Molecular size
- C) Ionization
- D) All of the above
What is the significance of a drug’s melting point?
- A) Indicates the drug’s solubility
- B) Reflects the drug’s stability
- C) Determines the drug’s partition coefficient
- D) Measures the drug’s molecular weight
Which property is used to predict a drug’s interaction with receptors?
- A) Lipophilicity
- B) Hydrogen bonding
- C) Molecular size
- D) All of the above
What does a high hydrogen bond donor count indicate about a drug?
- A) High solubility in water
- B) High lipid solubility
- C) Low molecular weight
- D) High ionization
Which property is important for the formulation of suspensions?
- A) Particle size
- B) Partition coefficient
- C) Dissociation constant
- D) Molecular weight
What is the role of surface activity in drug molecules?
- A) Enhances solubility
- B) Increases molecular weight
- C) Reduces lipophilicity
- D) Decreases ionization
Which property affects the drug’s clearance from the body?
- A) Lipophilicity
- B) Hydrogen bonding
- C) Ionization
- D) Molecular size
What does a high partition coefficient indicate about a drug’s solubility?
- A) High solubility in water
- B) High solubility in lipids
- C) Low molecular weight
- D) High ionization
Which property is crucial for the stability of emulsions?
- A) Particle size
- B) Partition coefficient
- C) Dissociation constant
- D) Molecular weight
What is the impact of ionization on drug absorption?
- A) Enhances absorption
- B) Reduces absorption
- C) No impact on absorption
- D) Increases solubility
Which property is used to predict a drug’s metabolism?
- A) Lipophilicity
- B) Hydrogen bonding
- C) Molecular size
- D) All of the above
What does a low log P value suggest about a drug?
- A) High water solubility
- B) High lipid solubility
- C) Low molecular weight
- D) High ionization
Which property affects the drug’s ability to bind to plasma proteins?
- A) Lipophilicity
- B) Hydrogen bonding
- C) Ionization
- D) Molecular size
What is the significance of a drug’s redox potential?
- A) Indicates the drug’s solubility
- B) Reflects the drug’s stability
- C) Determines the drug’s partition coefficient
- D) Measures the drug’s molecular weight
Which property is important for the formulation of tablets?
- A) Particle size
- B) Partition coefficient
- C) Dissociation constant
- D) Molecular weight
What does a high hydrogen bond acceptor count indicate about a drug?
- A) High solubility in water
- B) High lipid solubility
- C) Low molecular weight
- D) High ionization

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