Pharmacy Practice MCQ » PHARMACAREERS

Pharmacy Practice MCQ, in this article we will solve, Practice MCQ under subject Physical Pharmaceutics. Read following article for your reference.

Protein Binding, Complexation, And Drug Action » PHARMACAREERS

Which protein is most commonly involved in drug binding in the plasma?
- A) Hemoglobin
- B) Albumin
- C) Myoglobin
- D) Fibrinogen
What is the primary effect of drug-protein binding on drug distribution?
- A) Increases drug solubility
- B) Decreases drug bioavailability
- C) Enhances drug metabolism
- D) Prolongs drug half-life
Which factor does NOT affect drug-protein binding?
- A) Drug concentration
- B) Protein concentration
- C) Temperature
- D) Drug color
What type of bond is primarily involved in reversible drug-protein binding?
- A) Covalent bond
- B) Ionic bond
- C) Hydrogen bond
- D) Metallic bond
Which of the following is a consequence of high protein binding of a drug?
- A) Increased free drug concentration
- B) Decreased drug clearance
- C) Enhanced drug absorption
- D) Reduced drug half-life
What is the term for the fraction of a drug that is not bound to plasma proteins?
- A) Bound fraction
- B) Free fraction
- C) Total fraction
- D) Active fraction
Which protein is known for binding acidic drugs?
- A) Albumin
- B) Alpha-1-acid glycoprotein
- C) Globulin
- D) Fibrinogen
What is the impact of protein binding on the volume of distribution (Vd) of a drug?
- A) Increases Vd
- B) Decreases Vd
- C) No effect on Vd
- D) Varies with drug type
Which of the following drugs is known for high protein binding?
- A) Warfarin
- B) Paracetamol
- C) Amoxicillin
- D) Metformin
What is the effect of hypoalbuminemia on drug-protein binding?
- A) Increases binding
- B) Decreases binding
- C) No effect
- D) Depends on the drug
Which method is commonly used to study drug-protein binding?
- A) Mass spectrometry
- B) X-ray crystallography
- C) Equilibrium dialysis
- D) Nuclear magnetic resonance (NMR)
What is the role of alpha-1-acid glycoprotein in drug binding?
- A) Binds basic drugs
- B) Binds acidic drugs
- C) Binds neutral drugs
- D) Binds all types of drugs equally
Which of the following can displace a drug from its protein binding site?
- A) Another drug
- B) Increased temperature
- C) Decreased pH
- D) Increased pressure
What is the significance of the free drug concentration in pharmacodynamics?
- A) It determines the drug’s therapeutic effect
- B) It determines the drug’s solubility
- C) It determines the drug’s stability
- D) It determines the drug’s color
Which of the following is a characteristic of a drug with low protein binding?
- A) Long half-life
- B) High clearance
- C) Low volume of distribution
- D) High bioavailability
What is the effect of protein binding on drug excretion?
- A) Increases excretion
- B) Decreases excretion
- C) No effect on excretion
- D) Varies with the drug
Which of the following is a common plasma protein that binds drugs?
- A) Hemoglobin
- B) Albumin
- C) Myosin
- D) Actin
What is the impact of drug-protein binding on drug interactions?
- A) Reduces drug interactions
- B) Increases drug interactions
- C) No effect on drug interactions
- D) Varies with the drug
Which of the following factors can alter drug-protein binding?
- A) Age
- B) Gender
- C) Diet
- D) All of the above
What is the primary site of drug-protein binding in the body?
- A) Liver
- B) Kidney
- C) Plasma
- D) Brain
Which of the following is a reversible process in drug-protein binding?
- A) Covalent binding
- B) Ionic binding
- C) Hydrogen bonding
- D) All of the above
What is the effect of protein binding on the therapeutic index of a drug?
- A) Increases therapeutic index
- B) Decreases therapeutic index
- C) No effect on therapeutic index
- D) Varies with the drug
Which of the following is a consequence of low protein binding of a drug?
- A) Increased free drug concentration
- B) Decreased drug clearance
- C) Enhanced drug absorption
- D) Reduced drug half-life
What is the role of protein binding in drug toxicity?
- A) Reduces toxicity
- B) Increases toxicity
- C) No effect on toxicity
- D) Varies with the drug
Which of the following is a factor that affects drug-protein binding?
- A) Drug concentration
- B) Protein concentration
- C) pH
- D) All of the above
What is the effect of protein binding on drug metabolism?
- A) Increases metabolism
- B) Decreases metabolism
- C) No effect on metabolism
- D) Varies with the drug
Which of the following is a characteristic of a drug with high protein binding?
- A) Short half-life
- B) Low clearance
- C) High volume of distribution
- D) Low bioavailability
What is the impact of protein binding on drug distribution?
- A) Increases distribution
- B) Decreases distribution
- C) No effect on distribution
- D) Varies with the drug
Which of the following is a common method to measure drug-protein binding?
- A) Equilibrium dialysis
- B) Mass spectrometry
- C) X-ray crystallography
- D) Nuclear magnetic resonance (NMR)
What is the significance of the bound drug concentration in pharmacokinetics?
- A) It determines the drug’s therapeutic effect
- B) It determines the drug’s solubility
- C) It determines the drug’s stability
- D) It determines the drug’s distribution

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