Pharmacy Practice MCQ, in this article we will solve, Practice MCQ on the topic, Pathophysiology of diseases of Bones and Joints. Read following article for your reference.
Pathophysiology of Diseases of Bones and Joints
What type of disorder is rheumatoid arthritis (RA)?
A) Degenerative
B) Autoimmune
C) Infectious
D) Metabolic
Which cells are primarily involved in the initiation of RA?
A) B cells
B) T cells
C) Osteoclasts
D) Chondrocytes
What is the role of TNF-α in RA?
A) Inhibits inflammation
B) Promotes inflammation
C) Stimulates bone formation
D) Reduces synovial fluid production
What is a pannus in the context of RA?
A) A type of joint deformity
B) A thickened synovial membrane
C) A type of immune cell
D) A bone erosion
Which of the following is a hallmark symptom of RA?
A) Morning stiffness lasting more than an hour
B) Night sweats
C) Weight gain
D) Fever
Which drug class is considered the cornerstone of RA treatment?
A) NSAIDs
B) DMARDs
C) Antibiotics
D) Antivirals
What characterizes osteoporosis?
A) Increased bone mass
B) Decreased bone mass
C) Increased bone density
D) Increased joint fluid
Which hormone deficiency is a significant risk factor for osteoporosis?
A) Insulin
B) Estrogen
C) Thyroxine
D) Cortisol
What is the primary role of osteoclasts in bone remodeling?
A) Bone formation
B) Bone resorption
C) Bone mineralization
D) Bone repair
Which of the following is a common site for osteoporotic fractures?
A) Skull
B) Hip
C) Elbow
D) Jaw
What is kyphosis?
A) Loss of height
B) Hunchback
C) Joint swelling
D) Bone pain
Which class of drugs is commonly used to treat osteoporosis?
A) Bisphosphonates
B) Antivirals
C) Antibiotics
D) Antifungals
What is the primary cause of gout?
A) Hypercalcemia
B) Hyperuricemia
C) Hypoglycemia
D) Hyperlipidemia
What are monosodium urate (MSU) crystals?
A) Calcium deposits
B) Uric acid crystals
C) Cholesterol crystals
D) Protein deposits
Which joint is commonly affected by gout?
A) Knee
B) Shoulder
C) Big toe
D) Wrist
What is podagra?
A) Gout in the big toe
B) Gout in the knee
C) Gout in the wrist
D) Gout in the shoulder
Which cytokine is involved in the inflammatory response in gout?
A) IL-1β
B) IL-10
C) IL-4
D) IL-6
Which drug is used for acute management of gout?
A) Methotrexate
B) Colchicine
C) Bisphosphonates
D) Estrogen
What is the long-term goal in the management of gout?
A) Increase uric acid levels
B) Decrease uric acid levels
C) Increase calcium levels
D) Decrease calcium levels
Which enzyme is targeted by xanthine oxidase inhibitors in gout treatment?
A) Cyclooxygenase
B) Xanthine oxidase
C) Lipoxygenase
D) Phosphodiesterase
What are tophi?
A) Nodular masses of urate crystals
B) Bone spurs
C) Cartilage growths
D) Synovial fluid accumulations
Which lifestyle modification is recommended for managing gout?
A) High-purine diet
B) Low-purine diet
C) High-fat diet
D) Low-fiber diet
Which of the following is NOT a risk factor for osteoporosis?
A) Estrogen deficiency
B) Sedentary lifestyle
C) High calcium intake
D) Chronic glucocorticoid use
Which immune cells are involved in the inflammatory response in RA?
A) Neutrophils and macrophages
B) Erythrocytes and platelets
C) Lymphocytes and eosinophils
D) Basophils and mast cells
What is the primary function of osteoblasts?
A) Bone resorption
B) Bone formation
C) Bone mineralization
D) Bone repair
Which cytokine is targeted by biologic agents in RA treatment?
A) IL-10
B) TNF-α
C) IL-4
D) IL-6
What is the main clinical manifestation of osteoporosis?
A) Joint pain
B) Fractures
C) Muscle weakness
D) Skin rash
Which of the following is a common complication of hip fractures in osteoporosis?
A) Increased mobility
B) Decreased morbidity
C) Increased mortality
D) Decreased pain
Which dietary supplement is essential for osteoporosis management?
A) Vitamin C
B) Vitamin D
C) Vitamin B12
D) Vitamin K
Which of the following is a non-pharmacological approach to managing RA?
A) Weight-bearing exercises
B) Smoking cessation
C) Adequate calcium intake
D) All of the above
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