Factors affecting solubility of drugs When it comes to designing effective pharmaceutical formulations, understanding the solubility of drugs is crucial. Poor solubility can lead to suboptimal drug delivery, variable bioavailability, and ineffective treatment. These factors interact with each other, and their impact can vary depending on the specific drug and its chemical properties. So, let’s … Read more
Solvation and Association In the intricate dance of pharmaceutical science, where molecules waltz in solution, two central partners emerge: solvation and association. These concepts, akin to the choreography of drug formulation, dictate the fate of therapeutic agents within our bodies. So, let us unravel their steps, adhering to the precise language found in textbooks. Solvation … Read more
Ideal solubility parameters Ideal solubility parameters (ISPs) are like the secret handshakes they exchange. ISPs consider three forces: dispersion (think subtle nods), polarity (like magnets finding their match), and hydrogen bonding (warm chemistry hugs). When a drug meets a solvent, they dance—matching ISPs mean better solubility. It’s molecular harmony. Formulators use ISPs to create drug … Read more